Do Single-Component and Mixtures Selected Organic UV Filters Induce Embryotoxic Effects in Zebrafish (Danio rerio)?

UVs are important ingredients in common cosmetic products (e.g., sunscreens, hairsprays, soap). After their use, they can enter the aquatic ecosystem and negatively affect non-target organisms. The aim of our study was to evaluate acute embryotoxicity selected organic 2-phenylbenzimidazole-5-sulfonic acid (PBSA), ethylhexyl methoxycinnamate (EHMC), octocrylene (OC), 4-methylbenzylidene camphor (4-MBC) benzophenone-3 (BP-3). chemicals were tested both as a single substance mixtures. types mixtures chosen follows: combination OC 4-MBC; PBSA, EHMC BP-3 all five UV filters. evaluated using modified method Fish Embryo Acute Toxicity Test-OECD guideline 236 zebrafish (Danio rerio) suitable fish model organism. toxic effects studied by assessing mortality, hatching occurrence malformations at 24, 48, 72 96 h post fertilization. obtained results indicate that especially mixture 4-MBC presents potential risk for due significant increase which 41.7% experimental group exposed 10 ?g/L Based on results, most effected sub-lethal endpoints malformation edema pericard, bent spine, yolk edema), but with no statistically effect. These differ within groups mixtures, suggesting interaction these substances when together.